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This volume of The ANNALS offers a synthetic treatment of three threats to science: politicization, misinformation, and inequality. It brings together leading scholars in each area who present empirically grounded discussions of major research agendas. The essays in each section also build upon one another to isolate the distinct nature of each threat, and, perhaps more importantly, to offer insights on what steps can be taken in response. The hope is that readers are not left feeling deflated by overwhelming challenges, but rather are inspired by guidance on how to address threats to advancing science and improving societal well-being. In this volume, the first section includes five essays that investigate – across issues – how people use scientific information. The second section of this volume takes up the threat of science misinformation. The final section of the volume explores a distinct type of threat, concerning inequalities and science. These threats – politicization, misinformation, and inequality – have serious consequences. Yet, the ingenuity that has generated transformative science can also be used to address threats and help science play a role in improving societal well-being. Paperback: $42.00, Sale Price $33.60, ISBN: 9781071887189 Hardcover: $60.00, Sale Price $58.00, ISBN: 9781071887202 Visit sagepub.com/annals