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The purpose of Decision Making in Anesthesiology: An Algorithmic Approach, 5th Edition, is to present the process of anesthetic management during the perioperative period in a decision tree format. This format encourages the reader to think systematically and to follow a logical sequence through preoperative evaluation and preparation, intraoperative management, and postoperative considerations. The goal is to construct decision trees that are easy to follow, demonstrate decision points clearly, and are simple but not simplistic. The comments are keyed to designated decision points for further information, supported by references. This format, employed consistently throughout the prior four editions, continues to be most interesting to reformulate and in some cases reorganize clinical knowledge and experiences in order to construct these algorithms.