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This handbook has been prepared with a practical outlook. RPL is a condition which is multifactorial. There are controversies in definition, etiology, investigations, pathophysiology and treatment. This handbook aims to improve a clinician’s knowledge by putting forth the latest advances in the understanding of the problem and the management options. The various chapters have been authored by dedicated academicians and clinicians. Recent modalities of management, such as PGD, assisted reproductive technologies and immunotherapy have been covered. The book will also help the clinician to cater to the emotional needs of the distressed couple as chapter on ‘setting up a RPL clinic’ and ‘tender loving care’ have been included.