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During publication of the first edition of Problem-based Questions in Pathology, there was much confusion about acceptability of the approach as it was a pioneer work dealing with the clinical problems with solutions suitable to an undergraduate pathology teaching curriculum. The second edition hopes that it would also be a success like the first one. A lot of corrections and changes have been incorporated in each chapter. The first two chapters are almost completely rewritten. Two new chapters dealing with CNS pathology and problem cards, respectively are also included. An utmost care has been taken in each step to discuss all the topics in an orderly point-wise and lucid manner avoiding any confusion. The book would help young students of pathology to discover the actual patients behind the problems, paving the step of their future success in clinical practice.