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As this book is gaining increasing popularity, therefore, I feel pleasure to present the fifth revised and enlarged edition of this book. In this edition some chapters have been rewritten and some new chapters have been added. These additions also cover UGC syllabus. With the above additions, it is expected that this new edition will be more helpful to the readers. These additions will further make the students to probe deep into the subject. Contents : 1. Introduction to Organic Reaction Mechanism 2. Concepts Used in Organic Reaction Mechanism 3. Tautomerism 4. Hydrogen Bonding 5. Stereochemistry 6. Free Radical Reactions 7. Addition Reaction (Unsaturation and Conjugation) 8. Elimination Reactions(Carbenes) 9. Reactions of the Carbonyl Group 10. Nucleophilic Substitution at Saturated Carbon 11. Aromatic Substitution 12. Esterfication, Ester Hydrolysis and Trans-Esterification and Hard and Soft Acids and Bases 13. Benzenoid and Non-Benzenoid Aromatic Compounds 14. Conformational Analysis 15. Some reactions of Synthetic Importance 16. Molecular Rearrangements 17. Some Reagents of Synthetic Importance