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This is the fourth edition of Textbook of Oral Medicine. The book has received over the years from educators, students and practitioners. This edition includes a lot of changes. For easy understanding of the concepts, flowcharts have been incorporated. Summary has been added at the end of each chapter which will help in quick revision of the chapter during crucial hours of examination. Many new figures have also been added with improved clarity to understand the subject in better way. Gene therapy is added in Appendix 7 which is essential to broaden up the knowledge of students.